8:00 am Check-In & Light Refreshments
8:50 am Chair’s Opening Remarks
Hit ID 101: Building your Hit Identification Process for New Modes of Action
9:00 am Panel Discussion: Strategizing When to Prioritise Running Various Screening Strategies in Particular Modalities
Synopsis
- Emphasizing the benefits of running screening strategies in parallel to enhance efficiency, allowing for the simultaneous exploration of multiple modalities and accelerating the hit ID process
- Increasing the likelihood of identifying successful hits by applying specific screening to mitigate the risk of failure by diversifying the approach across different screening modalities
- Demonstrating how and when to allocate resources to particular screening strategies to achieve effective drug discovery outcomes & optimise hit screening
Leveraging Fragment-Based Screening to Target Previously Undruggable Proteins
9:45 am Cancer Drug Discovery Using Fragment-Based Methods
Synopsis
- Inhibiting KRAS, MYC, and the WNT pathway Tim Foley Lab Head, DNA-Encoded Library Selection & Pharmacology Pfizer
- Drugging highly validated cancer targets that are challenging to drug
- Using fragment-based methods and structure-based design
10:30 am Speed Networking
Synopsis
This informal session provides the perfect opportunity to connect with your peers all working specifically in hit identification and drug discovery. Establish meaningful connections to build upon for the rest of the conference and gain exclusive first-hand insights into the latest research and developments driving progression in the hit screening
11:15 am Morning Break
11:45 am Roundtable – Prioritizing your Screening Strategy; When & Where to Use Different Techniques
Synopsis
- Delving into discussion on the first port of call when approaching novel targets
- Comparing alternative strategies used in previous hit identification strategies for lesser known targets
- Drawing on knowledge of FBDD to justify when is best to use it
Selecting Optimal Cell Lines for Representative Hit Identification in High Throughput Screening
12:15 pm Donor to Donor Variability in Pharmacology: Mole Hill or Mountain?
Synopsis
- Investigating donor to donor variability in primary human cell assays supporting immunology programs
- Analyzing data from >25 primary cell assays developed for SAR and HTS to answer the title’s question
- Sharing specific lessons and strategies to facilitate the use of these physiologically relevant cells and assays
12:45 pm Networking Lunch
Discovering the Potential of DNA-Encoded Libraries in Novel Approaches & Applications
1:45 pm Identifying Novel, Non-Trapping, PARP1 Inhibitors Using DNA-Encoded Libraries (DEL)
Synopsis
- Designing DEL selections for difficult targets
- Identifying novel chemical equity for PARP1
- Understanding PARP’s trapping mode of action
2:15 pm The Role of on-DNA Hit Confirmation in DNA-Encoded Library Screening
Synopsis
- Designing a DEL to enhance the reliability of identified hits by focusing on well-characterized and diverse compounds
- Refining DEL to improve the robustness of screening results, to improve affinity and increase the reproducibility of findings
- Optimizing screening efficiency to streamline the screening process, leading to faster and more accurate hit identification
- Exploring the potential of DEL library collaboration
2:45 pm Afternoon Break & Poster Session
Synopsis
This is an informal session to help you connect with your peers in a relaxed atmosphere and forge new and beneficial relationships. With an audience of experts in medicinal chemistry & hit identification eager to discuss shared challenges, you will have the opportunity to display a poster presenting your own work. Additionally, you will have the chance to review others’ posters. To submit a poster, please contact info@hansonwade.com
3:45 pm Creating an Alternative to the DEL Separation Step to Reduce False Negatives & Improve Stability
Synopsis
- Reducing false negatives by preserving more potential hits during the DEL separation step
- Enhancing the stability of DNA-tagged compounds, ensuring more reliable identification of active molecules
- Streamlining the DEL process without the separation step to boost overall screening efficiency, enabling faster and more accurate hit identification