An Integrative Process to Discover Ligands of Nuclear Receptors with Different Modes of Action & Cellular Functions
Time: 1:00 pm
day: Conf Day 2
Details:
- Discovering inhibitors of xenobiotic receptor PXR by automated phenotypic and target-based HTS
- Optimizing binding affinity by medicinal chemistry
- Revealing modes of action (agonists, inverse agonists and antagonists) by structural and pharmacology
