Combining Multiple Hit ID Approaches to Successfully Tackle Challenging Targets
Time: 9:45 am
day: Conf Day 1
Details:
- 2-epimerase is a promising antibacterial target proposed to synergise with clinically important antibiotics
- Conformational flexibility, cryptic pockets and a large polar binding site make this a challenging target
- Combining multiple hit ID approaches, including FBLD, MTS and a proprietary fragment-DEL technology, has generated nM inhibitors which show strong synergistic potentiation of beta-lactam antibiotics
