Is your Hit a Hit? Investigating Experimental Strategies for Reducing & Understanding False Positive Hits
Time: 9:10 am
day: Pre-Conf Day
Details:
As drug discovery begins to steer towards more and more difficult targets and go beyond the low hanging fruit, identifying any false positives quickly proves necessary to preventing wasting both resources and time. From ensuring your data quality is appropriate and robust prior to starting on a campaign to prevent troubleshooting halfway through, all the way to designing an appropriate hit triage to follow your primary assay and addressing all potential false positive mechanisms; join this workshop to strategize your approach to false positives.
This workshop will cover:
- Developing triage strategies to maximize confidence in your hits, with particular emphasis on small molecule phenotypic screening
- Recognizing blind spots in your screening assays and avoiding misinterpretations
- Prioritizing hits and understanding when it is appropriate to resynthesize your compound
