Two Birds with One Stone: Accelerating Target & Hit ID of Ligand-Target Sets with Proximity-Based Proteomics
Time: 1:15 pm
day: Day Two
Details:
- Identifying chemical matter and neosubstrates that can move towards molecular glue discovery
- Expanding both target and hit strategies to engage E2 enzymes using proximity-based proteomics
- Applying proximity-dependent biotinylation techniques using enzyme tags and probes to selectively label proteins in close proximity to endogenously expressed targets
